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CB1R Allosteric modulator 3

CAS No. 2633686-36-7

CB1R Allosteric modulator 3( —— )

Catalog No. M35571 CAS No. 2633686-36-7

CB1R Allosteric modulator 3 is a potent CB1R modulator that inhibits cAMP and β-Arrestin and can be used for the study of obesity and nicotine addiction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CB1R Allosteric modulator 3
  • Note
    Research use only, not for human use.
  • Brief Description
    CB1R Allosteric modulator 3 is a potent CB1R modulator that inhibits cAMP and β-Arrestin and can be used for the study of obesity and nicotine addiction.
  • Description
    CB1R Allosteric modulator 3 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively.
  • In Vitro
    CB1R Allosteric modulator 3 (compound 44) (0.10 nM-10 μM, 30 min) has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively.CB1R Allosteric modulator 3 can enhance CB1R ago-PAM activity because of small lipophilic functional groups on the ortho-position of the GAT211 site-III phenyl ring.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    cAMP
  • Recptor
    cAMP | Cannabinoid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2633686-36-7
  • Formula Weight
    376.84
  • Molecular Formula
    C22H17ClN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (265.36 mM; Ultrasonic )
  • SMILES
    C(CN(=O)=O)(C1=C(NC=2C1=CC=CC2)C3=CC=CC=C3)C4=C(Cl)C=CC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Peter C Schaffer, et al. Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility. Bioorg Med Chem. 2020 Nov 1;28(21):115727. ?
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